Everyday Erinyes #303

 Posted by at 12:41 pm  Politics
Jan 302022
 

Experts in autocracies have pointed out that it is, unfortunately, easy to slip into normalizing the tyrant, hence it is important to hang on to outrage. These incidents which seem to call for the efforts of the Greek Furies (Erinyes) to come and deal with them will, I hope, help with that. As a reminder, though no one really knows how many there were supposed to be, the three names we have are Alecto, Megaera, and Tisiphone. These roughly translate as “unceasing,” “grudging,” and “vengeful destruction.”

Science. Science deniers. This is not new. The two kinds of people have existed side by side for literally thousands of years. Taking one fact as an example, consider the “flat earth.” Scientests have known the earth ws not flat, but instead a more of less spherical shape, as early as the 5th century B.C.E. I say scientists have known, not that everyone has known. Galileo ws threatened with excommunication and improsonment as recently as the 1600s C.E. for suggesting that the earth mpved around the sun. (Yet 200 years earlier, Dante’s Inferno/ Purgatorio/ Paradiso was based on the premise of a spherical earth, through which he descended to the lowest levels of Hell at the center (he did get the temperature wrong – he pictured it as frozen – he wasn’t a scientist himself, but he must have listened to some) and then ascended through the levels of purgatory to come out into paradise on the other side. Today most people have grasped at least the concept of the solar system, and yet some still have not, and consider th earth to be flat.

Medical advances have a bad name in some circles because testing advances can be problematic. Of course no one would consider trying an idea on humans before doing animal testing, which brings up the question of how do you get informed consent from a frog? There might be a way, but we certainly don’t know what it is.

But I really find it exciting what this particular group of scientests is trying to do – and I have to believe that TC also would be excited – peersonally. Of course they are not going to get results usable by humans in my lifetime – nor in the lifetime of anyone here – and, discouraging as it is I have to wonder if the human race itself will last long enough to get results usable by humans.

But it’s still exciting.
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A new treatment helped frogs regenerate their amputated legs – taking science one step closer to helping people regrow their body parts, too

Reactivating the signals cells use to regenerate could help patients regrow lost limbs and damaged tissue.
George Jones/Stockbyte via Getty Images

Michael Levin, Tufts University; David Kaplan, Tufts University, and Nirosha Murugan, Algoma University

Our bodies connect us to the world. When people lose parts of their bodies to disease or traumatic injury, they often feel that they’ve lost a part of who they are, even experiencing a grief akin to losing a loved one. Their sense of personal loss is justified because unlike salamanders or snarky comic book characters like Deadpool, adult human tissues generally do not regenerate – limb loss is permanent and irreversible.

Or is it?

While there have been significant advances in prosthetic and bionic technologies to replace lost limbs, they cannot yet restore a sense of touch, minimize the sensation of phantom pains or match the capabilities of natural limbs. Without reconstructing the limb itself, a person won’t be able to feel the touch of a loved one or the warmth of the sun.

We are researchers in regenerative and developmental biology and biomedical engineering. Our recent study in the journal Science Advances showed that just 24 hours of a treatment we designed is enough to regenerate fully functional and touch-sensitive limbs in frogs.

Kickstarting regeneration

During very early development, cells that will eventually become limbs and organs arrange themselves into precise anatomical structures using a set of chemical, biomechanical and electrical signals. In considering ways to regenerate limbs, we reasoned that it would be much easier to ask cells to repeat what they already did during early development. So we looked for ways to trigger the “build whatever normally was here” signal for cells at the site of a wound.

One of the major challenges in doing this, however, is figuring out how to create an environment that encourages the body to regenerate instead of forming scars. While scars help protect injured tissue from further damage, they also change the cellular environment in ways that prevent regeneration.

Axolotls are known for their powerful regenerative abilities.

Some aquatic animals such as the axolotl have mastered regeneration without scar formation. And even in early human development, the amniotic sac provides an environment that can facilitate regenerative mechanisms. We hypothesized that developing a similar environment could override scar formation at the time of injury and allow the body to reactivate dormant regenerative signals.

To implement this idea, we developed a wearable device made of a silk hydrogel as a way to create an isolated chamber for regeneration by blocking other signals that would direct the body to develop scars or undergo other processes. We then loaded the device with a cocktail of five drugs involved in normal animal development and tissue growth.

We chose to test the device using African clawed frogs, a species commonly used in animal research which, like humans, does not regenerate limbs in adulthood. We attached the device onto one leg stump for 24 hours. We then removed the device and observed how the site of the lost limb changed over time. Over the course of 18 months, we were amazed to find that the frogs were able to regenerate their legs, including fingerlike projections with significant nerve, bone and blood vessel regrowth. The limbs also responded to light pressure, meaning that they had a restored sense of touch, and allowed the frog to return to normal swimming behavior.

Frogs that were given the device but without the drug cocktail had limited limb regrowth without much functional restoration. And frogs that weren’t treated with the device or the drug cocktail did not regrow their limbs, leaving stumps that were insensitive to touch and functionally impaired.

Interestingly, the limbs of the frogs treated with the device and the drug cocktail weren’t perfectly reconstructed. For example, bones were sometimes fragmented. However, the incompleteness of the new limb tells us that other key molecular signals may be missing, and many aspects of the treatment can still be optimized. Once we identify these signals, adding them to the drug treatment could potentially fully reverse limb loss in the future.

Person putting on prosthetic leg
While prosthetic and bionic limbs can help amputees regain their independence, they do not fully restore function.
Nadia Ramahi/500px Prime via Getty Images

The future of regenerative medicine

Traumatic injury is one of the leading causes of death and disability in Americans. And limb loss from severe injury is the most frequent source of lifelong disability. These traumatic injuries are often caused by automobile accidents, athletic injury, side effects of metabolic diseases such as diabetes and even battlefield injuries.

[Over 140,000 readers rely on The Conversation’s newsletters to understand the world. Sign up today.]

The possibility of decoding and awakening dormant signals that enable the body to regenerate parts of itself is a transformative frontier in medical science. Beyond regrowing lost limbs, regenerating heart tissue after a heart attack or brain tissue after a stroke could extend life and dramatically increase its quality. Our treatment is far from being ready to use in humans, and we only know that it works when applied immediately after injury. But uncovering and understanding the signals that allow cells to regenerate means that patients may not have to wait for scientists to really understand all the intricacies of how complex organs are constructed before they can get treated.

Making a person whole again means more than just replacing their limb. It also means restoring their sense of touch and ability to function. New approaches in regenerative medicine are now beginning to identify how that may be possible.The Conversation

Michael Levin, Professor of Biology, Tufts University; David Kaplan, Professor of Biomedical Engineering, Tufts University, and Nirosha Murugan, Assistant Professor of Biology, Algoma University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Alecto, Megaera, and Tisiphone, perhaps unleashing your fury on the science deniers – even if only those in denial cults who are destroying science and truth for the rest of us – that might help. I don’t know what else could.

The Furies and I will be back.

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Jan 252022
 

Glenn Kirschner – NY Subpoenas, GA Special Grand Jury Subpoenas, Congressional Subpoenas: All Subpoenas Are Not Equal

The Guardian – Tonga: new footage shows aftermath of volcano eruption and tsunami

Meidas Touch – A Coup in Plain Sight

The Lincoln Project – What Are They For?

The Ring of Fire – January 6th Committee Targets Social Media Companies With Subpoenas

MSNBC’s Tiffany Cross explains Mitch McConnell –

Beau – Let’s talk about executive orders, doubt, and machinery….

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Jan 242022
 

Glenn Kirschner – With Supreme Court Ruling, the Investigative Circle is Tightening Around Trump in NY\GA\Congress

The Lincoln Project- Trump’s Judges

Thom Hartmann – Will Any Polling Station Be Left By 2022 Election?

Rebel HQ – Richard Ojeds addresses Joe Manchin

Farron Balanced – Ivanka Trump Called To Testify Before January 6th Committee

Corey Ryan Forrester – This Week in Southern History – Jimmy Carter Is Inaugurated

Beau – Let’s talk about Ivanka Trump and the heart of the Republic….

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Jan 172022
 

Glenn Kirschner – Oath Keepers Members Indicted for Seditious Conspiracy: Facts Show How Trump Inspired 1/6 Conduct

politicsrus – Let Truth Light the Way Part I

Rebel HQ – Richard Ojeda Reacts To Jen Psaki’s Viral Moment

Ring of Fire – Florida Republicans Introduce Bill To Spy On Public School Teachers

Armageddon Update – The Days Of Omicron

Orphaned Baby Otter Follows Kids Up From River

Beau – Let’s talk about my last day teaching in Virginia…. (despite the upside down cap, you might end up wanting a hanky.)

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Jan 122022
 

Yesterday, I did take some time to disengageshort sessions with a couple of games just to relax. And deal with a package. And even to stream a movie (“The Canterville Ghost” with Patrick Stewart.) It’s a wonder I got both posts up.

Cartoon – (I’m pretty sure no one ever too TC up on this offer.)

Short Takes –

Here’s where election-denying candidates are running to control voting
Quote – An NPR analysis of 2022 secretary of state races across the country found at least 15 Republican candidates running who question the legitimacy of President Biden’s 2020 win, even though no evidence of widespread fraud has been uncovered about the race over the last 14 months. In fact, claims of any sort of fraud that swung the election have been explicitly refuted in state after state, including those run by Republicans.
Click through for states and names. These may be the most important elections of 2022. As Beau says, “If you live in one of these dtates, and you have ever desired to get interested in electoral politics, now is your time.” (Pass it on.)

Mother Jones – The Jan. 6 Insurrectionists Begging for Pardons Sound an Awful Lot Like Confederate Soldiers
Quote – Radical Republicans feared Lincoln’s 10 percent plan was too lenient. They were proved right when, after Lincoln’s assassination, President Andrew Johnson—who not a year earlier gave a speech saying, “I am for a white man’s government, and in favor of free white qualified voters controlling this country, without regard to negroes”—began undermining Reconstruction. He started by pardoning high-ranking Confederates. Among them was Harry T. Hayes, a former Confederate general who led the rebels at Gettysburg.
Click through for full story. I truly hope we can learn from their mistakes.

The Guardian – Why is so little known about the 1930s coup attempt against FDR?
Quote – The putsch called for [retired US Marine Corps Maj Gen Smedley Darlington Butler] to lead a massive army of veterans – funded by $30m from Wall Street titans and with weapons supplied by Remington Arms – to march on Washington, oust Roosevelt and the entire line of succession, and establish a fascist dictatorship backed by a private army of 500,000 former soldiers.
Click through for details. Those who follow the video thread know that Beau of the Fifth Column has spoken about the United States’ long history of choosing to “protect the Office of the Presidency,” and I expect that had a hand in hiding this history, though of course the rich and powerful were also prime movers. In my view, the best way to protect the Office of the Presidency is to ensure that anyone who defules that Office is held accountable.

Food For Thought:

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Dec 262021
 

Glenn Kirschner – Time for the Military Leadership to Return Mike Flynn to Active Duty and Court-Martial Him (I might just add that retirees and active duty military are paid out of the same budget. I’m not saying that that [Dod] budget is not inflated – just that retireepay is a huge chunk of it, and why DoD doesn’t use that fact as a public selling point is beyond me. But it does bolster the military’s ability to recall retirees to active duty at will.))

Don Winslow – #JoeManchinsBrotherSuedHim

Robert Reich – The Oligarchy’s Ultimate Political Weapon

VoteVets – Maj.Gen.(Ret.) Paul Eaton Discusses WaPo Op-Ed & 2024 Insurrection Threat With Wolf Blitzer on CNN

The Lincoln Project – The Trump Vaccine

Really American – COVID-19 vaccine

Beau – Let’s talk about Sherman and Atlanta….

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Everyday Erinyes #296

 Posted by at 11:54 am  Politics
Dec 122021
 

Experts in autocracies have pointed out that it is, unfortunately, easy to slip into normalizing the tyrant, hence it is important to hang on to outrage. These incidents which seem to call for the efforts of the Greek Furies (Erinyes) to come and deal with them will, I hope, help with that. As a reminder, though no one really knows how many there were supposed to be, the three names we have are Alecto, Megaera, and Tisiphone. These roughly translate as “unceasing,” “grudging,” and “vengeful destruction.”

In 1929, “Ellery Queen” began “his”* mystery-novel-writing career with “The Roman Hat Mystery,” just eight years after tetrsethyl lead started to be used in fuel for automobiles. The weapon his villain used to kill his victims in this book was tetraethyl lead. The deaths were quite gruesome. If “Queen” expected the novel to draw people’s attention to the dangers of using the stuff in gasoline and having it come out of the exhaust, it didn’t work. Ethanol existed then, but could not be patented, whereas tetraethyl lead could. It was not until the 1970’s that “Unleaded” gas appeared on the market, and “regular” was available alongside it for quite a while. I don’t currently have a source for this, but I remember reading that studies sone around this time and a bit later showed a direct correlation between the amount of ethyl gas used in an area and the amount of violent crime taking place in the same area. Big corporations making big money simply do not have the best interests of their customers in mind. But we are partly to blame for not forcing them to.
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A century of tragedy: How the car and gas industry knew about the health risks of leaded fuel but sold it for 100 years anyway

For decades, most gas sold in the U.S. contained a lead additive.
Per Magnus Persson via Getty Images

Bill Kovarik, Radford University

On the frosty morning of Dec. 9, 1921, in Dayton, Ohio, researchers at a General Motors lab poured a new fuel blend into one of their test engines. Immediately, the engine began running more quietly and putting out more power.

The new fuel was tetraethyl lead. With vast profits in sight – and very few public health regulations at the time – General Motors Co. rushed gasoline diluted with tetraethyl lead to market despite the known health risks of lead. They named it “Ethyl” gas.

It has been 100 years since that pivotal day in the development of leaded gasoline. As a historian of media and the environment, I see this anniversary as a time to reflect on the role of public health advocates and environmental journalists in preventing profit-driven tragedy.

A black and white photo of a man in an old laboratory.
Scientists working for General Motors discovered that tetraethyl lead could greatly improve the efficiency and longevity of engines in the 1920s.
Courtesy of General Motors Institute

Lead and death

By the early 1920s, the hazards of lead were well known – even Charles Dickens and Benjamin Franklin had written about the dangers of lead poisoning.

When GM began selling leaded gasoline, public health experts questioned its decision. One called lead a serious menace to public health, and another called concentrated tetraethyl lead a “malicious and creeping” poison.

General Motors and Standard Oil waved the warnings aside until disaster struck in October 1924. Two dozen workers at a refinery in Bayway, New Jersey, came down with severe lead poisoning from a poorly designed GM process. At first they became disoriented, then burst into insane fury and collapsed into hysterical laughter. Many had to be wrestled into straitjackets. Six died, and the rest were hospitalized. Around the same time, 11 more workers died and several dozen more were disabled at similar GM and DuPont plants across the U.S.

A cartoon showing a man going insane after lead exposure.
The news media began to criticize Standard Oil and raise concerns over Ethyl gas with articles and cartoons.
New York Evening Journal via The Library of Congress

Fighting the media

The auto and gas industries’ attitude toward the media was hostile from the beginning. At Standard Oil’s first press conference about the 1924 Ethyl disaster, a spokesman claimed he had no idea what had happened while advising the media that “Nothing ought to be said about this matter in the public interest.”

More facts emerged in the months after the event, and by the spring of 1925, in-depth newspaper coverage started to appear, framing the issue as public health versus industrial progress. A New York World article asked Yale University gas warfare expert Yandell Henderson and GM’s tetraethyl lead researcher Thomas Midgley whether leaded gasoline would poison people. Midgley joked about public health concerns and falsely insisted that leaded gasoline was the only way to raise fuel power. To demonstrate the negative impacts of leaded fuel, Henderson estimated that 30 tons of lead would fall in a dusty rain on New York’s Fifth Avenue every year.

Industry officials were outraged over the coverage. A GM public relations history from 1948 called the New York World’s coverage “a campaign of publicity against the public sale of gasoline containing the company’s antiknock compound.” GM also claimed that the media labeled leaded gas “loony gas” when, in fact, it was the workers themselves who named it as such.

An old advertisement for Ethyl brand gas.
Leaded gas was marketed as Ethyl, a joint brand of Standard Oil and General Motors.
John Margolies/Library of Congress

Attempts at regulation

In May 1925, the U.S. Public Health Service asked GM, Standard Oil and public health scientists to attend an open hearing on leaded gasoline in Washington. The issue, according to GM and Standard, involved refinery safety, not public health. Frank Howard of Standard Oil argued that tetraethyl lead was diluted at over 1,000 to 1 in gasoline and therefore posed no risk to the average person.

Public health scientists challenged the need for leaded gasoline. Alice Hamilton, a physician at Harvard, said, “There are thousands of things better than lead to put in gasoline.” And she was right. There were plenty of well-known alternatives at the time, and some were even patented by GM. But no one in the press knew how to find that information, and the Public Health Service, under pressure from the auto and oil industries, canceled a second day of public hearings that would have discussed safer gasoline additives like ethanol, iron carbonyl and catalytic reforming.

By 1926, the Public Health Service announced that they had “no good reason” to prohibit leaded gasoline, even though internal memos complained that their research was “half baked.”

A graph showing that blood lead levels closely follow lead emissions from cars.
As leaded gasoline fell out of use, lead levels in people’s blood fell as well.
U.S. EPA

The rise and fall of leaded gasoline

Leaded gasoline went on to dominate fuel markets worldwide. Researchers have estimated that decades of burning leaded gasoline caused millions of premature deaths, enormous declines in IQ levels and many other associated social problems.

In the 1960s and 1970s, the public health case against leaded gasoline reemerged. A California Institute of Technology geochemist, Clair Cameron Patterson, was finding it difficult to measure lead isotopes in his laboratory because lead from gasoline was everywhere and his samples were constantly being contaminated. Patterson created the first “clean room” to carry on his isotope work, but he also published a 1965 paper, “Contaminated and Natural Lead Environments of Man,” and said that “the average resident of the U.S. is being subjected to severe chronic lead insult.”

In parallel, by the 1970s, the U.S. Environmental Protection Agency decided that leaded gasoline had to be phased out eventually because it clogged catalytic converters on cars and led to more air pollution. Leaded gasoline manufacturers objected, but the objections were overruled by an appeals court.

The public health concerns continued to build in the 1970s and 1980s when University of Pittsburgh pediatrician Herbert Needleman ran studies linking high levels of lead in children with low IQ and other developmental problems. Both Patterson and Needleman faced strong partisan attacks from the lead industry, which claimed that their research was fraudulent.

Both were eventually vindicated when, in 1996, the U.S. officially banned the sale of leaded gasoline for public health reasons. Europe was next in the 2000s, followed by developing nations after that. In August 2021, the last country in the world to sell leaded gas, Algeria, banned it.

A century of leaded gasoline has taken millions of lives and to this day leaves the soil in many cities from New Orleans to London toxic.

The leaded gasoline story provides a practical example of how industry’s profit-driven decisions – when unsuccessfully challenged and regulated – can cause serious and long-term harm. It takes individual public health leaders and strong media coverage of health and environmental issues to counter these risks.

[You’re smart and curious about the world. So are The Conversation’s authors and editors. You can read us daily by subscribing to our newsletter.]The Conversation

Bill Kovarik, Professor of Communication, Radford University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Alecto, Megaera, and Tisiphone, as a race, we humans are not terribly good at doing what is best for us. Up until the 1920’s, for instance, arsenic was still used in skin lotions. And before that it was white lead (lead carbonate), which still shows up in some paints and some ceramics. People did not want to give them up. Women did not want to give their cosmetics up. I’m not old enought o remember the pushback on arsenic or white lead, but I am definitely old enough to remember the pushback on unleaded gas. If people are so terrified of change that they become violently opposed to giving up poisons, I guess we shouldn’t be surprised at the lengths they will go to in order not to take a vaccine. Well, give us long enough and we will make ourselves extinct – and maybe more sensible creatures will evolve to take our place.

The Furies and I will be back.

*”Ellery Queen” was actually two dudes, Frederic Dannay and Manfred B. Lee – hence the two cross strokes in the “Q” on the book titles, at least the early ones. There’s no unicode for it so I can’t use it here.)

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Dec 082021
 

Glenn Kirschner – House Postpones Flynn & Luna Testimony; Flynn Should be Returned to Active Duty and Court-Martialed (I’ll bet Miles Taylor could tell us what a “body man”s duties were – and I’ll bet it had something to do with adult diapers.)

The Lincoln Project – Pearl Harbor Rememberance Day

CNN – Meadows SPOOKED, Subpoena Coming Next? (If he thought he could “make a deal,” he has no idea who the committe members are.)

RepresentUs – This Is What Corporate Welfare Looks Like

politicsrus – Democracy Is Hard Earned

Six13 a capella – West Side Chanukah Story (I really do think Lenny must be smiling down. BTW you can close it when they start talking – pitching – at the end.)

Beau – Let’s talk about a letter from Texas…..

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